About Lacidipine Selective calcium channel blocker, Dihydropyridine derivative, Antihypertensive. Mechanism of Action of Lacidipine Lacidipine is a vasoselective long acting dihydropyridine Ca channel blocker. It exerts antihypertensive action through blocking the influx of Ca ions through voltage gated L-type Ca channels to the peripheral vascular smooth muscle cells, Coronary smooth muscle cells and to the myocardial cells. Thus causes dilatation of vascular endothelium, decrease peripheral resistance, and blood pressure. It exerts some anti atherosclerotic properties by modulating the secretion of matrix degrading metalloproteinase-9 by human macrophages and thus weakens the atherosclerotic plaque. It also has antioxidant properties and it prevents platelet aggregation. Indications for Lacidipine 1. Hypertension Interactions for Lacidipine Avoid grape fruit juice as it may affect metabolism. Other interactions as with calcium channel blockers.