About Tretinoin Retinoid, vitamin A metabolite, Anti-acne,in hyperpigmentation. Mechanism of Action of Tretinoin Tretinoin is All Trans retinoic acid (acid form of vitamin A). Tretinoin is a potent comedolytic. It stimulates mitosis and epidermal cell turnover and also promotes lysis of keratocytes. It inhibits the binding of horny cells to each other and prevents the formation of comedones. It acts as a follicular epithelium irritant. Through these actions, the comedo contents are extruded and the formation of the microcomedo, the precursor lesion of acne vulgaris, is reduced Indications for Tretinoin 1. Acne 2. Wrinkles 3. Photo ageing of skin 4. Dry scaly surface Interactions for Tretinoin Sulfer, Resorcinol, Benzoyl peroxide or Salicylic acid : Concomitant use of topical keratolytic medications may result in significant skin irritation. Use medicated or abrasive soaps and cleansers, soaps and cosmetics that have a strong drying effect and products with high concentrat