About Magaldrate Chemical complex of aluminum and magnesium hydroxides, Antacid. Mechanism of Action of Magaldrate This neutralizes the gastric acid and increases the gastric pH. This reduces the direct acid irritant effect. It also enhances mucosal barrier integrity and improves gastroesophageal sphincter tone. Simethicone About Simethicone Oral anti-foaming agent, Silicones, Antiflatulent. Mechanism of Action of Simethicone This anti-gas (anti-flatulence) medication acts in the stomach and intestines to change the surface tension of gas bubbles, enabling smaller bubbles to join together into bigger bubbles. It results elimination of gas more easily by belching or passing flatus.