About Naproxen NSAID, 2-arylpropionic acid (profen) derivative, Analgesic, anti-inflammatory,antipyretic. Mechanism of Action of Naproxen Naproxen has analgesic, anti-inflammatory and antipyretic action. It acts by inhibiting Prostaglandin (PGs) synthesis and their release at the site of injury. Prostaglandins cause tenderness and amplify the action of other algesics. Naproxen inhibits cyclo-oxygenase enzyme and antagonizes prostaglandin actions. Indications for Naproxen 1. Rheumatoid arthritis 2. Ankylosing spondylitis 3. Acute gout 4. Joint disorders e.g. inflammatory disease and crystal deposition in the joints 5. Osteoarthritis 6. For the relief of pain and inflammation in dental minor surgery and orthopedic 7. Dysmenorrhoea 8. Juvenile arthritis 9. Migraine