About Choline A water-soluble essential nutrient, natural quaternary saturated amine. Mechanism of Action of Choline Choline is a water-soluble vitamin. Choline aids in nerve transmission and utilization of fat and hormone production. It also maintain normal kidney and bladder function. It is most effective with Vitamin A, B-Complex, B-12, Folic Acid, and Inositol. Also, it helps lower cholesterol, transferring nerve impulse to the brain, helps against memory loss and senile dementia, and aids the liver in removing poisons and drugs from the bloodstream.