About Ibuprofen NSAID, a propionic acid derivative, Analgesic and anti-inflammatory. Mechanism of Action of Ibuprofen Ibuprofen has analgesic, anti-inflammatory and antipyretic action. It acts by inhibiting Prostaglandin (PGs) synthesis and their release at the site of injury. Prostaglandins cause tenderness and amplify the action of other algesics. Ibuprofen inhibits cyclo-oxygenase enzyme and antagonizes prostaglandin actions. It also inhibits platelet aggregation and prolongs bleeding time. About Pseudoephedrine Alpha/Beta Adrenergic Agonist, a phenethylamine derivative, A nasal decongestant. Mechanism of Action of Pseudoephedrine It is a nasal decongestant with alpha-2 agonistic action. It produces local vasoconstriction, reduces blood flow, and causes shrinkage of mucosa which provides relief of nasal congestion. It reduces oedema of the nasal mucosa, thus improving ventilation, drainage and nasal stuffiness.