About Lamivudine Nucleoside Reverse Transcriptase Inhibitor ,cytidine analogue, Antiretroviral. Mechanism of Action of Lamivudine Lamivudine is a deoxy cytidine nucleoside analogue. It undergoes phosphorylation in the presence of Kinase enzyme and form Lamivudine triphosphate. This Lamivudine triphosphate competitively inhibit HIV reverse transcriptase enzyme which is responsible for the conversion of viral RNA to pro viral DNA and is then added to host cell chromosome. Lamivudine triphosphate terminates elongation of pro viral DNA and results in inhibition of viral replication. Lamivudine triphosphate is also a potent inhibitor of HBV (hepatitis B virus) Indications for Lamivudine 1.HIV infections 2.Treatment of chronic Hepatitis B Interactions for Lamivudine Trimethoprim, sulfamethoxazole: Results in an increase in AUC of Lamivudine and a decrease in renal clearance. Zidovudine: Results in an increase in C max. of Zidovudine.